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 SCI 337 - Pharmacology


The functioning of the (diseased) human body can be affected by medicines, which act through a variety of molecular mechanisms. In this course a study of two diseases (hypertension and cancer) will be used to illustrate the physiological and pharmacological principles which are used for rational drug development and use. The importance of neuronal, hormonal, immunological (whole body) and biochemical (whole cell) regulation for proper physiological and cellular function, and dysregulation during pathological processes are emphasized. Identification of potential drug targets and the interaction of drugs with macromolecules (enzymes, cell surface receptors, and signaling molecules) as the main pharmacological principles are central in this course. Quantitative pharmacological, pharmacokinetic and statistical methods are used. At the end of the course students will be able to explain the effectivity of existing drug therapies in a rational way in terms of the molecular targets, the cellular actions and the physiological consequences of pharmacological treatment. They will be able to suggest targets for drug development on the basis of pathophysiological insights and to apply pharmacological models when describing concentration-response, time-concentration, and time-response relationships of drugs.




Biomedical Science  



The following courses are required in order to take this course:


  • Introduction to Life Science
  • Molecular Biology and Cell Biology
  • Functional Anatomy
  • Human Physiology